http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112826795-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4748 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4748 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28 |
| filingDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112826795-B |
| titleOfInvention | A kind of tetrandrine-loaded liposome preparation and preparation method and application thereof |
| abstract | The invention relates to the field of pharmaceutical preparations, and discloses a tetrandrine-loaded liposome preparation, comprising the following raw materials: soybean lecithin, dipalmitoyl phosphatidylethanolamine, cholesterol, tetrandrine and perfluorooctane, wherein , the sum of the mass of soybean lecithin and dipalmitoyl phosphatidylethanolamine, the mass ratio between cholesterol and tetrandrine is 4:1:2.5～3.5. The preparation method of the above-mentioned tetrandrine-loaded liposome preparation is as follows: dissolving soybean lecithin, dipalmitoyl phosphatidylethanolamine, cholesterol and tetrandrine in a solvent, obtaining a uniform thin liquid film by rotary evaporation, and hydrating a thin film. The liquid film was added with perfluorooctane bromide, ultrasonically oscillated in an ice bath, and then centrifuged to collect the precipitate to obtain a tetrandrine-loaded liposome preparation. When the tetrandrine-loaded liposome preparation is used in the preparation of a medicament for treating dry eye disease, the effect on intraocular pressure is small, and the invention greatly improves the encapsulation rate and drug-loading rate of tetrandrine. |
| priorityDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.