| abstract |
The present invention provides chemical entities (e.g., compounds or pharmaceutically acceptable salts and/or hydrates and/or co-crystals and/or pharmaceutical combinations of such compounds) that inhibit (e.g., antagonize) interferon gene Stimulator (STING). The chemical entities may be used, for example, to treat a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) results in the pathology, morbidity/or symptoms and/or progression of the disease or disorder (e.g., cancer) in a subject (e.g., a human). The invention also provides compositions comprising the chemical entities and methods of using and making the compositions. |