http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112812072-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 |
| filingDate | 2021-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112812072-B |
| titleOfInvention | A kind of triazole derivative containing deuterium and alkenyl group and preparation method and application |
| abstract | The invention discloses a deuterium- and alkenyl-containing triazole derivative, a preparation method and application thereof, and its chemical structure is shown in formula (I): Wherein, R is selected from aryl, electron-donating or electron-withdrawing substituted aryl, electron-donating or electron-withdrawing heteroaryl, C 1 -C 6 straight-chain or branched alkyl, C 1 -C 2 straight-chain or Branched alkoxy. Using terminal alkyne, 2,4,6-tribromophenyl azide compound and sodium borodeuterium as raw materials, the reaction is carried out at 40-80°C under the action of catalyst and additives. The method of the invention can positionally introduce D element, and has low cost, simple operation, mild conditions and easy control, and is suitable for large-scale production; the triazole derivatives are rich in functional groups, stable in chemical properties, and have certain pharmaceutical activity, and are suitable for use in pharmaceutical synthesis and synthesis. Industrial production and other fields are of great significance. |
| priorityDate | 2021-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 135.