http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112812005-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b270bc8bcaa5d55bb92a8093ce95373 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C53-42 |
| filingDate | 2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8436c8d686d3ada4eb640bd0a1ee4cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3dc20e538a498014df3803ede66dd9c |
| publicationDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112812005-A |
| titleOfInvention | A kind of preparation method of clindamycin hydrochloride palmitate intermediate palmitic acid chloride |
| abstract | The present invention provides an extremely simple preparation method of clindamycin hydrochloride palmitate intermediate palmitic acid chloride. The method comprises the following steps: mixing and stirring palmitic acid, benzene and thionyl chloride, and heating at a temperature of 0.5-1 °C/°C. The rate of heating to 70 ~ 80 ℃, the reaction was incubated, and the palmitic acid chloride was separated. In the present invention, the palmitic acid, benzene and thionyl chloride only need to be mixed and stirred, the temperature is raised to 70-80°C at a rate of 0.5-1°C/min, and then the palmitic acid acid chloride can be obtained by thermal insulation reaction. The process can effectively improve the reaction rate, shorten the reaction time and reduce the consumption of the reactant thionyl chloride without adding a reaction assistant. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111187174-A |
| priorityDate | 2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.