| abstract |
The invention discloses a preparation method of a neutrophil membrane biomimetic nanomaterial specifically targeting an infection site, comprising the following steps: mixing the neutrophil membrane and drug-loading nanoparticles, performing ultrasonic mixing on the obtained mixture, and then passing through the volume of The free cell membrane microspheres and drug-loaded nanoparticles were separated by size exclusion chromatography to obtain purified neutrophil membrane biomimetic nanomaterials. The preparation method has the advantages of simple operation, low cost and short preparation period. The prepared neutrophil membrane biomimetic nanomaterial uses PLGA as the shell of the nanoparticle, which encapsulates the therapeutic drug, and the surface of the shell wraps the neutrophil membrane, so that the nanoparticle has the in vivo targeting ability of actively targeting the infection site, so as to improve the The purpose of the drug concentration in the infected tissue around the joint prosthesis is to improve the targeted therapeutic effect of the drug on the infection site. |