| abstract |
The invention discloses an oxazole pyrimidone amide compound or a medicinal salt thereof, a preparation method and application thereof, wherein the oxazole pyrimidone amide compound has the following structural general formula (I): wherein R is 1 ，R 2 Each independently selected from hydrogen and C 1‑3 An alkyl group; r 3 Is selected from C 1‑3 An alkyl group; r 4 ，R 5 Each independently selected from 5-6 membered aryl, the aryl is phenyl or an heteroaryl containing 1-3 heteroatoms, the heteroatoms are taken from oxygen or nitrogen atoms, and the position of the heteroatoms is any position on the heteroaryl; the aromatic group being unsubstituted or at least substituted by one or more halogens or C 1‑3 Alkyl radical, C 1‑3 Polyhaloalkyl, C 1‑3 Alkoxy substitution. The invention also discloses the application of the TRPA1 antagonist in preparing medicaments for treating or preventing diseases, symptoms and/or disorders modulated by TRPA1, such as pain and the like. |