| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0368
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0387
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0393
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1136 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52 |
| filingDate |
2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-112779284-B |
| titleOfInvention |
Construction method and application of THPO gene humanized non-human animal |
| abstract |
The present invention provides a method for constructing THPO gene humanized non-human animals and the application of the constructed humanized non-human animals. The method includes introducing the sequence encoding human THPO protein into In the animal genome, the animal can normally express human or humanized THPO protein and promote the development of human T cells and NK cells. It can be used as an animal model for the study of human THPO signaling mechanism and drug screening for tumors and other diseases. The development of new drugs has important application value. The present invention also provides a THPO gene targeting carrier, a THPO gene targeting sgRNA and their application in preparing humanized THPO gene. |
| priorityDate |
2019-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |