| abstract |
The invention provides an NK trophoblast cell expressing a cytokine composition and a preparation method and application thereof, wherein the NK trophoblast cell expresses membrane proteins CD19, CD86, IL21, CD64 and CD 137L; the CD19 comprises an amino acid sequence shown as SEQ ID NO. 1; the CD86 comprises an amino acid sequence shown in SEQ ID NO. 2. The NK trophoblast cells constructed by the invention have high expression rate on CD19, CD86, IL21, CD64 and CD137L, and all factors synergistically activate the proliferation capacity of NK cells, thereby realizing the effect of inducing NK cells to differentiate and mature in vitro. |