http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112778474-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G09F3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F8-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F8-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F293-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F220-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F220-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2812 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F293-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G09F3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-54 |
| filingDate | 2020-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112778474-B |
| titleOfInvention | Rare earth cage complex metal fluorescent dual-mode label for flow cytometry and preparation method |
| abstract | The invention discloses a rare earth cage-like complex metal fluorescent dual-mode label for flow cytometry, which is composed of a polymer with a rare-earth cage-like complex represented by the following formula (I-8) and a monoclonal The antibody is coupled to obtain, wherein, Ln 3+ is a lanthanide rare earth metal ion; The present invention is different from the existing mass spectrometry polymer metal chelate tags. The present invention cleverly replaces the DOTA coordinating group with a cage-like coordinating group, on the one hand, improves the coordination ability to rare earth ions, and reduces the The leakage of rare earth ions makes the metal label stronger in flow cytometry; on the other hand, due to the antenna effect of cage complexes, the fluorescence intensity of rare earth complexes is greatly increased, making it possible to detect by flow cytometry. The invention can prepare a rare earth cage complex metal fluorescent dual-mode label that can be used for flow cytometry at low cost, thereby greatly reducing the use cost of mass spectrometry flow detection reagents. |
| priorityDate | 2020-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.