| abstract |
The present invention provides a novel class of heteroaromatic compounds as atx (autotaxin) inhibitors, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions to treat a disease in a mammal having a pathological feature of increased atx (autotaxin) expression, wherein the compounds have a structure according to formula (I) or (II), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, nitrogen oxide, metabolite, prodrug, or mixture thereof: wherein R is 1a 、R 2 、R 3 、R 6 、Cy 1 、Cy 2 、Y 1 、Y 2 Z and t all have the definitions given in the present invention. |