| abstract |
The invention belongs to the technical field of organic chemistry, and discloses a method for synthesizing thioamide compound by catalyzing 1,2, 3-thiadiazole compound and amine with copper. The method comprises the steps of reacting a 1,2, 3-thiodiazole compound with an amine compound under the action of a copper salt catalyst or a copper catalyst and a phosphine ligand by taking an organic solvent as a reaction medium in a protective atmosphere, and carrying out subsequent treatment to obtain the thioamide compound. The method of the invention takes copper salt as a catalyst and adopts phosphine ligand, so that the yield is high and the applicability of the substrate is wide. In addition, the reaction takes the 1,2, 3-thiodiazole compound and the amine compound as raw materials, and has the advantages of cheap and easy raw materials, simple and convenient operation and high atom economy. |