http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112759595-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-553 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2021-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2023-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2023-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112759595-B |
| titleOfInvention | Method for Synthesizing Chiral Acyclic Nucleosides by Asymmetric Allylation |
| abstract | The invention discloses a method for synthesizing chiral acyclic nucleosides through an asymmetric allylation reaction, and belongs to the field of asymmetric synthesis in organic chemistry. Using substituted purine 1 or substituted purine pyrimidine 4 and vinyl carbonate 2 as raw materials, tris(dibenzylideneacetone) dipalladium as catalyst, naphthyl Trost ligand L8 as chiral ligand, reacted in organic solvent to obtain The chiral acyclic nucleoside compound 3 or 5 can reach 97% ee and 94% ee respectively, and the yield is moderate to excellent, which provides a simple and effective way for the synthesis of such compounds. |
| priorityDate | 2021-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.