| abstract |
The invention discloses a CHI3L1/LN detection card, a preparation method and an application thereof, belonging to the field of nano materials and nano medicine, wherein the adopted rare earth nano probe is erbium sodium fluoride coated yttrium sodium fluoride with a core-shell structure, the particle size is 20 nm-30 nm, and the detection card comprises the following components: NaErF 4 @NaYF 4 Wherein, NaErF 4 Is a full erbium-doped core structure; NaYF4 is a shellLayer, @ denotes coating NaYF4 on NaErF 4 A surface. The nano probe of the invention is a rare earth fluoride nano material, has the advantages of low background, long luminescent life, strong fluorescence signal, high signal to noise ratio and the like, is stable in labeled product because the probe is connected with an antibody through a covalent bond, has the characteristics of high sensitivity, high accuracy, quick, simple and convenient detection and the like, and can assist doctors in judging whether a patient has hepatic fibrosis in the early stage. |