http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112725415-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eec19c18115f3b92ff1d1f2ab988f7d5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6417 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6844 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6402 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6844 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate | 2020-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7db5718689861380df63cb8842a9916c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9554b89b36ff247f914bc4fc84fb1379 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b35ad4b502e4d0471632e75562414a38 |
| publicationDate | 2021-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112725415-A |
| titleOfInvention | Fluorescent Nanoprobes and Their Applications |
| abstract | The present invention relates to the technical field of nucleic acid detection, in particular to fluorescent nanoprobes and applications thereof. The fluorescent nanometer probe of the invention modifies three DNA chains on the surface of the up-conversion nanoparticle and Fe 3 O 4 nano particle, and the DNA chain on the surface of the Fe 3 O 4 nano particle can be specifically combined with the target sequence, and then through the complementary pairing of nucleic acid bases In principle, upconversion and Fe3O4 nanoparticles are assembled together to form nanoprobes, the target sequence and nanoprobes are mixed, and the fluorescence intensity in the supernatant after magnet adsorption is detected to achieve quantitative analysis of target nucleic acids. When the probe of the present invention detects the sample to be tested, the target sequence can be circulated to achieve the effect of signal amplification. Moreover, the invention has simple operation, short time required, high sensitivity and specificity, good linear range in the range of 100aM to 1nM, and the lowest detection concentration is 1.6aM. |
| priorityDate | 2020-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.