abstract |
The present invention proposes the preparation and application of dual-target CAR-T cells targeting CD30 and CD24. The CAR-T cell chimeric antigen receptor includes anti-CD30 single-chain antibody, anti-CD24 single-chain antibody, hinge region, transmembrane region, intracellular region. Dual-target CAR-T can well solve the off-target effect of single CAR-T without aggravating cytokine release syndrome to a large extent, and achieve better tumor killing effect. |