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publicationDate 2021-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-112725283-A
titleOfInvention Construction method and application of dual-target CAR-T cells targeting CD30 and CD24
abstract The present invention proposes the preparation and application of dual-target CAR-T cells targeting CD30 and CD24. The CAR-T cell chimeric antigen receptor includes anti-CD30 single-chain antibody, anti-CD24 single-chain antibody, hinge region, transmembrane region, intracellular region. Dual-target CAR-T can well solve the off-target effect of single CAR-T without aggravating cytokine release syndrome to a large extent, and achieve better tumor killing effect.
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