| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_440dee328842dce1af919f44343209a2 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-537
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-537
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2019-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b122cc05a22837cac7c091b4bfc08acb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6c374034aa7f7eae0cd39bcc04e5383 |
| publicationDate |
2021-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-112691190-A |
| titleOfInvention |
Antibody-high-activity cytotoxic small molecule drug conjugate drug, preparation and application thereof |
| abstract |
The invention provides an antibody-high-activity cytotoxic small molecule drug conjugate drug, and preparation and application thereof. The method comprises the steps of preparing the antibody-high-activity cytotoxic small molecule drug conjugate by chemically modifying a conjugate antibody and an active cytotoxic small molecule chemical drug by using a hydrophilic heterobifunctional non-cleavable linker; wherein the hydrophilic heterobifunctional non-cleavable linker has a structure represented by formula (I) or formula (II): wherein L is 1 Selected from phenylene, Or- (CH) 2 ) m ‑C(＝O)‑NHC 2 H 4 ‑(OC 2 H 4 ) n -; r1 is selected from H or-SO 3 Na; m is 0, 1, 2 or 3; n is 1 to 30. |
| priorityDate |
2019-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |