http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112679290-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C15-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C2-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343 |
| filingDate | 2021-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112679290-B |
| titleOfInvention | Nickel-catalyzed asymmetric hydrogen alkynylation method for olefins and application of nickel-catalyzed asymmetric hydrogen alkynylation method in preparation of AMG837 |
| abstract | The invention discloses a nickel-catalyzed olefin asymmetric hydrogen alkynylation method and application thereof in preparation of AMG837, belonging to the field of organic chemistry and pharmaceutical chemistry. Under the action of metal nickel salt, chiral ligand, alkali, hydrogen source, additive, etc., the present invention makes olefin react with alkynyl bromide compound in organic solvent to obtain benzyl alkynyl substituted compound with excellent regioselectivity and enantioselectivity. The method uses cheap transition metal nickel as a catalyst, uses commercially available olefin and alkynyl bromide as raw materials, and has the advantages of mild condition, good functional group compatibility and simple and convenient operation. |
| priorityDate | 2021-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 136.