| abstract |
The invention belongs to the technical field of functional materials, and discloses a tannic acid cross-linked chitosan gelatin liquid-absorbing hemostatic antibacterial sponge and a preparation method thereof. In the present invention, chitosan is chemically cross-linked with gelatin through esterification reaction to form a primary cross-linked network to obtain modified super-hydrophilic gelatin; and tannic acid is used as a cross-linking agent to further cross-link under the action of a strong oxidant. Then, medical excipients, hydroxyapatite and sodium alginate are added for physical mechanical foaming and freeze-drying to obtain a porous sponge-like chitosan/gelatin absorbent hemostatic antibacterial sponge. The sponge-like porous material obtained by using tannic acid cross-linked chitosan/gelatin in the present invention has good mechanical properties, porous and fine structure, soft surface, no need to infiltrate in advance when the human body is in contact, wide raw material sources, low market price, and good biological properties. Compatibility, non-toxic and biodegradable; and the preparation method is simple and efficient, which is favorable for large-scale production, and has a good market application prospect. |