http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112645970-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6443 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-69 |
| filingDate | 2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112645970-B |
| titleOfInvention | Fluorescent probe for detecting Abeta oligomer as well as preparation method and application thereof |
| abstract | The invention discloses a fluorescent probe for detecting Abeta oligomer and a preparation method and application thereof. The structural general formula of the fluorescent probe is shown as a formula (I). The preparation method comprises the following preparation steps: (1) heating p-hydroxybenzaldehyde and N-acetylglycine in an organic solvent for reaction, and taking sodium acetate as a catalyst to obtain a yellow solid; then heating the yellow solid and a methylamine water solution in an organic solvent for reaction, wherein potassium carbonate is used as a catalyst, and obtaining an intermediate 1; (2) heating the intermediate 1 and boron tribromide dichloromethane in an organic solvent to react to obtain an intermediate 2; (3) and heating the intermediate 2 and p-dimethylaminobenzaldehyde in an organic solvent for reaction, and taking piperidine as a catalyst to obtain the fluorescent probe for detecting the A beta oligomer. The fluorescent probe can be used for beta-amyloid plaque imaging, has high sensitivity, and has wide application prospect in early diagnosis of Alzheimer's disease and disclosure of pathological mechanism. |
| priorityDate | 2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.