http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112645932-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate | 2016-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112645932-B |
| titleOfInvention | Polymorphic form of EGFR inhibitor free base or acid salt thereof, preparation method and application thereof |
| abstract | The invention discloses a polymorphic form of an EGFR inhibitor free base or an acid salt thereof, a preparation method and application thereof. Specifically N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl) Polymorphic form of (methyl)amino)-4-methoxyphenyl)acryloylamide free base or acid salt thereof and preparation method thereof, and preparation of said polymorphic form in the treatment of EGFR mutant activity-mediated diseases The application in medicine is used to inhibit the activity of L858R EGFR mutant, T790M EGFR mutant and exon 19 deletion activating mutant, etc. It can be widely used in the prevention and treatment of cancer, especially non-small cell lung cancer and other related diseases, and is expected to be developed into A new generation of EGFR inhibitors. |
| priorityDate | 2016-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 224.