http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112645872-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-89 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-89 |
| filingDate | 2020-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112645872-B |
| titleOfInvention | A kind of preparation method of pyridine nitrogen oxide derivative intermediate |
| abstract | The invention discloses a method for preparing an intermediate of pyridine nitrogen oxide derivatives. The synthetic route is as follows: By optimizing the reaction conditions, compared with the technical route disclosed by Gao Xuezhi et al., the oxidation reaction time is unexpectedly shortened from 15h to about 3 hours, and the HPLC purity can reach 99%; the bromination reaction is shortened from 15h to about 6h , the yield was increased from 70% to 92%, and the HPLC purity was also as high as 98%. Using green and pollution-free water as a solvent, the oxidation reaction can directly carry out the second-step bromination reaction without post-treatment, which reduces the post-treatment process and improves production efficiency. |
| priorityDate | 2020-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.