| abstract |
The invention belongs to the technical field of chemical medicine, and particularly relates to a green preparation method of an intermediate of an anticancer drug Palbocicillin. The invention uses zirconium nitrate and ammonium metatungstate as raw materials, adopts a homogeneous precipitation method to prepare Zr/W composite oxide, and is impregnated with sulfuric acid to prepare an acidified tungsten/zirconium double metal oxide, which is used for catalyzing the oxidation of hydrogen peroxide to 2- Amino-5-bromopyridine prepares 2-nitro-5-bromopyridine. The catalytic oxidation process of the invention is green and pollution-free, and does not generate waste acid; and the oxidation process is relatively mild, basically no 3,5-dibromo-2-aminopyridine by-product is generated in the oxidation process, and the crude product has high purity and yield. |