http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112608359-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-0045 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112608359-B |
| titleOfInvention | Process for the preparation of 17 alpha-hydroxyandrosta-4, 9-diene-3, 20-dione |
| abstract | The invention discloses a method for preparing 17 alpha-hydroxyandrostane-4, 9-diene-3, 20-diketone, which comprises the following steps: (1) dispersing the ketal protector (I) in an organic solvent, and carrying out a Grignard reaction in a tubular reactor filled with a catalyst; (2) will be describedCarrying out deprotection reaction on the obtained Grignard reaction raw material liquid in a tubular reactor filled with strong acid ion exchange resin to prepare intermediate ketone (II); (3) and (3) carrying out post-treatment on the feed liquid after the deprotection reaction to obtain 17 alpha-hydroxyandrosta-4, 9-diene-3, 20-diketone (III), wherein the reaction formula is as follows: the invention uses the continuous tubular reaction technology to replace the existing interval kettle type reaction to prepare the 17 alpha-hydroxyandrostane-4, 9-diene-3, 20-diketone, is easy to realize the automatic control of the process, is convenient for continuous production and improves the stability of the process. |
| priorityDate | 2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.