http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112608357-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-067 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-16 |
| filingDate | 2020-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112608357-B |
| titleOfInvention | A kind of preparation method of antiviral medicine Molnupiravir |
| abstract | The present invention provides a method for preparing Molnupiravir, which comprises using compound 1 as a starting material to prepare compound 4 through two methods, and finally compound 4 is acidified by microchannel reaction technology to obtain Molnupiravir product 5; the method optimizes the esterification reaction And hydroxylamination reaction: The esterification reaction uses a conventional enzyme-catalyzed reaction, which has a high yield and less three wastes; the hydroxylamination reaction uses Bop reagent to directly carry out hydroxylamination, which improves the yield and effectively reduces the generation of three wastes. Intermediate 4 improves the yield of acid hydrolysis through microchannel reaction technology, and effectively improves the route efficiency. The reaction route is: |
| priorityDate | 2020-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.