| abstract |
The present invention provides a preparation method of Molnupiravir, which comprises using compound 1 as a starting material, preparing compound 4 through two methods, and finally obtaining Molnupiravir product 5 by acid hydrolysis of compound 4 by using a microchannel reaction technology; the method optimizes the esterification reaction And hydroxylamination reaction: the esterification reaction uses a conventional enzyme-catalyzed reaction, with high yield and less three wastes; hydroxylamination reaction uses Bop reagent to directly carry out hydroxylamination, which improves the yield and effectively reduces the generation of three wastes. Through the microchannel reaction technology, the intermediate 4 improves the acid hydrolysis yield and effectively improves the route efficiency. The reaction route is: |