http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112601541-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da3d06785ec3236e369910e5004d8193 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1658 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1623 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-212 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4291 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1694 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1623 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0095 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2e8b8497ad7391ce21fc752430a80f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16f77882dd5991cdf9434f8e92a7739c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56e5ccfc957d1502b473feea1509f81d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5726cc8522d00f3190ec859f449d73c |
| publicationDate | 2021-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112601541-A |
| titleOfInvention | Biopolymer formulations for oral administration |
| abstract | The invention relates in particular to a method for preparing a pharmaceutical composition which can be provided to a subject in oral form, comprising as active ingredients: a protein having a mass of 10 kilodaltons or more, a nucleic acid molecule consisting of 15 or more nucleotides, or a combination thereof. The one or more active ingredients are dispersed in the particles to facilitate absorption of the particles by the intestinal tract and release of the active ingredients in the bloodstream. The process for preparing such pharmaceutical compositions comprises: preparing an aqueous composition comprising one or more active ingredients; a monosaccharide or disaccharide; one or more other compounds and chitosan; and spraying the prepared aqueous composition to an anti-solvent and/or supercritical fluid, wherein the water fraction of the composition is soluble or miscible and the solute of the composition is insoluble, thereby precipitating the solute and producing particles having an average diameter of 50 nanometers (nm) to 20 micrometers (μm); collecting the particles; and preparing a pharmaceutical composition comprising said particles. Also provided is a collection of particles having an average diameter of 50nm to 20 μm comprising the components in a uniform distribution. Also provided are pharmaceutical formulations of oral dosage forms comprising such particle assemblies for the treatment of diseases. |
| priorityDate | 2018-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 539.