| abstract |
The invention discloses an oseltamivir PROTAC compound, a preparation method thereof and application thereof in anti-influenza virus medicines, belonging to the technical field of medicines. The oseltamivir PROTAC compound is shown as a general formula (I) or (II), wherein in the general formula, E3 ligase is a VHL or CRBN ligand; linker is a linking group. The compound can effectively degrade influenza virus neuraminidase so as to exert the activity of inhibiting the replication of influenza virus, has the activity of inhibiting wild strain influenza virus, has good inhibiting effect on oseltamivir drug-resistant strain, and has small toxicity to cells. The compound or the pharmacologically or physiologically acceptable salt thereof can be used for preparing medicaments for resisting influenza viruses. |