http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112592263-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7e9119bf73632a42c8e27d6d92dd61b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-40 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-673 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-697 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-753 |
| filingDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_483f96abb22635b6bc77c0dbabf702be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fab3739217fc08b48c4b1062101a91d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ac3751bd0adaf4a31f3dfd54d7ab57b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b502760546b38097bfa25cfa05198479 |
| publicationDate | 2021-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112592263-A |
| titleOfInvention | A kind of synthetic method of fluorene compound |
| abstract | The invention relates to the technical field of organic chemical synthesis, in particular to a method for synthesizing a fluorinated fluorene compound, and a method for synthesizing a fluorinated fluorene compound, comprising the following steps: S1, adding an organic solvent to a reaction kettle, and adding an organic solvent to the reaction kettle. Add the compound of formula (I) and the fluorinating agent, and stir and mix; S2, add auxiliary agent and reaction solvent successively in the mixture of S1; S3, set the reaction temperature and the reaction time of the reactor, while reacting it Uninterrupted stirring, after the reaction is complete, the product is naturally cooled to room temperature, then filtered, fully washed with saturated aqueous sodium carbonate solution, extracted with chloroform 2-3 times, combined with the organic phases, dried over anhydrous sodium sulfate, and concentrated under reduced pressure, The obtained residue is subjected to silica gel column chromatography and rinsed with a mixture of acetone and petroleum ether to obtain the compound of formula (II). Through the comprehensive selection and synergy of fluorinating agent, auxiliary agent and reaction solvent, the method can obtain the target product in high yield. |
| priorityDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.