| abstract |
The invention discloses an in-situ rapid prototyping urinary system repair magnetic hydrogel and a preparation method thereof. The magnetic hydrogel is a double-network hydrogel and comprises a first double-network monomer acrylamide, a cross-linking agent and a photoinitiator, and a second double-network monomer carboxymethyl chitosan and magnetic nanoparticles gamma-Fe 2 O 3 (ii) a The preparation method of the in-situ rapidly-formed magnetic hydrogel comprises the following steps: the hydrogel precursor solution is injected into the injury of the urinary system of a human body, such as the vesicovaginal fistula, in situ, and is rapidly formed under the blue light of 405 nanometers for 5 seconds to form the hydrogel which is suitable for the shape of the inner wall of the vesicovaginal fistula. The magnetic hydrogel provided by the invention has the performances of in-situ rapid forming, high swelling rate, traceability and the like, and can promote cell adhesion, thereby accelerating the repair of damaged parts. The magnetic hydrogel formed rapidly in situ has simple preparation process, simple operation and convenient large-scale production from the industrial aspect. |