| abstract |
The invention discloses an antibody with double MIC binding activity and application thereof, wherein the antibody comprises at least one heavy chain variable region containing three CDRs and at least one light chain variable region containing three CDRs, and the CDR sequences of the light chain variable region and the heavy chain variable region are shown in SEQ ID NO. 1-30. The anti-MIC antibody has good affinity effect on a plurality of MICA and MICB proteins, particularly has binding activity on soluble MICA 008, MICA 010, MICA 002, MICA 009 and MICB 005, and can relieve the tumor immunosuppressive effect caused by abnormal rising of MIC proteins by adsorbing NKG2D ligand in human blood or blood plasma, including soluble MICA, MICB molecules and immune complexes formed by MICA/B and anti-MIC monoclonal antibody medicaments. |