http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112574280-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08 |
| filingDate | 2020-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112574280-B |
| titleOfInvention | Double-enzyme system probe and application thereof |
| abstract | The invention belongs to the field of nuclear medicine, and relates to a double-enzyme system probe and application thereof. The probe has a structure shown in a formula I, wherein QD is a fluorophore or a drug group; l is linker and has a structure shown in a formula II; t is a PSMA specific targeting group; z is H, a nuclide chelating group, a radionuclide or a nuclide chelating group chelated with a radionuclide. The double-enzyme nuclear medicine probe for delivering the medicine molecules based on the prostate specific membrane antigen PSMA targeting and Caspase-3 recognition strategies can target prostate cancer to carry out radiotherapy sensitization treatment, is beneficial to solving the problems of radiotherapy resistance and targeted nuclide treatment resistance of castration-resistant prostate cancer patients, and is expected to realize navigation in prostate cancer operation. Provides more efficient tools for the detection and treatment of tumor treatment, and has wide application prospect. |
| priorityDate | 2020-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 203.