http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112574198-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2021-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112574198-B |
| titleOfInvention | Indolated derivative of tetrahydro-beta-carboline and preparation and application thereof |
| abstract | The invention belongs to the field of medicinal chemistry, and discloses an indolization derivative of tetrahydro-beta-carboline, and a preparation method and application thereof. Coupling the tetrahydro-beta-carboline compound with the indole derivative under the conditions of copper ion catalysis and oxygen, and carrying out terminal functionalization on the tetrahydro-carboline derivative under a mild oxidative coupling condition. The preparation method is simple, the used reagent is a reagent commonly used in a laboratory, the reaction condition is mild, the practicability is strong, the skeleton structure is synthesized for the first time, the antitumor activity is obvious, and the compound can be used for developing medicaments for treating breast cancer, lung cancer, cervical cancer and the like. |
| priorityDate | 2021-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.