| abstract |
The invention discloses a gallic acid hydrogen sulfide derivative, a preparation method and medical application thereof. The general formula of the gallic acid hydrogen sulfide derivative is A-Y-X, wherein A is gallic acid; y is-C (O) O-, -C (O) NH-, -C (O) OC (O) -, -C (O) NHCH 2 C (O) -or is absent, when Y is absent, the compound is A-X; x is a moiety capable of releasing hydrogen sulfide either alone or in combination with A. Compared with gallic acid and the existing classical non-steroidal anti-inflammatory drugs, the gallic acid hydrogen sulfide derivative has equivalent or enhanced anti-inflammatory activity, weakened gastrointestinal tract and cardiovascular side effects, stronger anti-tumor activity and good cardiovascular and neuroprotective effects. |