http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112569365-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 |
| filingDate | 2019-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112569365-B |
| titleOfInvention | Aptamer drug conjugate and preparation method and application thereof |
| abstract | The invention relates to the field of medicines, in particular to a nucleic acid aptamer medicine conjugate and a preparation method and application thereof. The aptamer drug conjugate provided by the invention comprises a drug molecule group and an aptamer fragment, wherein the drug molecule group is selected from mitomycin C groups, and the drug molecule group is connected with the aptamer fragment through a connecting group. The aptamer drug conjugate provided by the invention not only has all advantages of aptamers, but also has no selectivity to cells because mitomycin C is a non-specific anti-cancer drug, and can effectively improve the targeting capability of mitomycin C by combining the aptamer and the mitomycin C through a specific connecting molecule, thereby achieving the effect of specifically killing tumor cells. |
| priorityDate | 2019-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.