http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112569362-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
| filingDate | 2020-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112569362-B |
| titleOfInvention | Method for inhibiting tumor metastasis by breaking up CTC cell mass |
| abstract | The invention discloses a method for inhibiting tumor metastasis by scattering CTC cell masses, which relates to the technical field of medical treatment and comprises the steps of constructing a nano preparation based on exosome loaded ouabain, evaluating the effect of scattering CTC clusters by the nano preparation based on exosome loaded ouabain through an in-vitro experiment, and evaluating the effect of scattering CTC clusters and inhibiting tumor metastasis by the nano preparation based on exosome loaded ouabain through an in-vivo experiment; according to the invention, the tumor specific polypeptide iRGD is modified on the surface of the exosome, so that the exosome can be specifically combined with the alpha v beta 3 integrin on the surface of CTCs (CTCs), and the capacity of targeting the exosome to the CTCs is improved; the ouabain is introduced into exosomes by utilizing an electroporation method, so that the solubility of the ouabain in water is improved, the dosage form of the ouabain is improved, and the toxic and side effects of the ouabain are reduced; tumor metastasis is inhibited by using an exosome-based ouabain-loaded nano-formulation by scattering CTC cell masses in blood. |
| priorityDate | 2020-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.