| abstract |
The invention discloses a method for synthesizing allylamine derivatives, which utilizes a metal nickel catalyst to realize hydrogen transfer in a reactant amine, and realizes the coupling reaction with alkyne under the same catalytic system to construct allylamine; This reaction is very suitable for both amine compounds and alkynes, and can realize the construction of chiral allylamines. The method of the present invention does not need to add an additional reducing agent as a hydrogen source, nor does it need to introduce an additional guiding group, and the scale can be scaled up to the gram level, and the yield can still be maintained. |