http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112552199-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-40 |
| filingDate | 2020-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112552199-B |
| titleOfInvention | Preparation method of large crystal and high bulk density mefenamic acid |
| abstract | The invention belongs to the technical field of medicine, and in particular relates to a preparation method of mefenamic acid with large crystals and high bulk density. Under the protection of nitrogen, the crude mefenamic acid is added to the solvent, dissolved by heating, decolorizing and hot filtration, heat preservation and crystallization, gradient cooling, heat preservation crystallization, filtration to obtain a filter cake, and drying to obtain large crystals and high bulk density of mefenamic. That sour. The method adopts acetic acid, acetone or 1,4-dioxane as a solvent for purification, and the obtained mefenamic acid crystals have good fluidity, stable crystals, easy crushing, high bulk density and better druggability. The preparation method of the invention has the advantages of safety, environmental protection and simple operation. Easy to industrialize production. |
| priorityDate | 2020-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.