abstract |
The present invention discloses compositions and methods for reducing microbial biofilm growth and/or preventing the formation of microbial biofilms. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix inhibiting compounds, matrix depolymerizing compounds, quorum sensing inhibitors, or combinations thereof. In other embodiments, the compositions are used to impregnate or coat surfaces of articles and/or materials with the compositions to render them less susceptible to microbial infection. |