http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112538052-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 |
| filingDate | 2021-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112538052-B |
| titleOfInvention | Preparation method of oxaagolide intermediate |
| abstract | The invention discloses a preparation method of a diragolide intermediate, wherein a compound II and a compound III are heated to 50-100 ℃ in an organic solvent in the presence of a catalyst and alkali for reflux coupling reaction to obtain a compound I. According to the preparation method of the intermediate of the oxagolide, the 2-methyl-N1, N3-di-o-tolylbenzene-1, 3-diamine is used as the coupling catalyst, so that the metal residue of the traditional coupling metal catalyst is effectively avoided, the quality of the intermediate is improved, the reaction condition is mild, the operation is simple, the catalyst is stable and is not easy to inactivate, anaerobic harsh reaction conditions are not needed, and the process preparation cost is greatly reduced. |
| priorityDate | 2021-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.