| abstract |
The present invention relates to a tablet containing quetiapine fumarate and a preparation method thereof. The tablet or its core comprises an active component quetiapine fumarate, internal auxiliary materials and external auxiliary materials. In the process, the active components are firstly pulverized, mixed with one or more internal-added auxiliary materials evenly, then a wetting agent is added for one-time granulation, the obtained wet granules are dried and then pulverized through a 50-15 mesh sieve, and mixed with the remaining internal-added auxiliary materials. Mix evenly, then add a wetting agent for secondary granulation, dry and granulate the wet granules obtained again; then mix with external auxiliary materials for tableting; wherein, the internal added auxiliary materials are fillers, binders and internal added disintegration. Additives are additional disintegrants and lubricants. The invention significantly solves the problems of low dissolution rate and incomplete dissolution at the end point caused by static electricity, aggregation, adsorption and high surface energy of large-scale insoluble preparation raw materials after pulverization through simple secondary granulation, and significantly improves the dissolution rate and efficiency. bioavailability. |