abstract |
Embodiments herein relate to methods, systems, and kits for engineering antimicrobial peptides, such as bacteriocins, for example, to have a desired range of activity in a desired range of culture conditions. Antimicrobial peptides can be engineered to have specific activity against a particular culture, environmental condition, or range of conditions. Some embodiments include screening an antimicrobial peptide or several candidate antimicrobial peptides for a desired activity. Some embodiments include an iterative process of engineering antimicrobial peptides, such as bacteriocins. In some embodiments, the process is performed by automated machine learning. |