http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112505196-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-8634 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-86 |
| filingDate | 2020-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112505196-B |
| titleOfInvention | A method for quantitative analysis of isosorbide dinitrate, 2-isosorbide mononitrate and 5-isosorbide mononitrate in human plasma |
| abstract | The invention discloses a quantitative analysis method for isosorbide dinitrate and its metabolites 2-isosorbide mononitrate and 5-isosorbide mononitrate in human plasma. The present invention processes plasma by a liquid-liquid extraction method, and adopts ultra-high performance liquid phase-mass spectrometry (UPLC-MS/MS) to detect isosorbide dinitrate and its metabolites 2-isosorbide mononitrate and 5-isosorbide mononitrate in plasma. The simultaneous determination of isosorbide mononitrate concentration includes the following steps: (1) preparation of standard working solution; (2) sample processing; (3) standard curve preparation; (4) quantitative analysis. The invention has good selectivity, high sensitivity, good accuracy and precision, and can be directly applied to the pharmacokinetic study and bioequivalence study of the oral preparation of isosorbide dinitrate. |
| priorityDate | 2019-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.