http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112500359-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-30 |
| filingDate | 2020-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112500359-B |
| titleOfInvention | Preparation method of lorazepam intermediate |
| abstract | The invention discloses a preparation method of a lorazepam intermediate. The preparation method comprises the following steps: the 7-chloro-5- (2-chlorphenyl) -1, 3-dihydro-2H-1, 4-benzodiazepine-2-ketone is used as a raw material to carry out oxidation reaction with hydrogen peroxide in an aprotic polar solvent without an acidic solvent, and after the reaction is finished, the 7-chloro-2-oxo-5- (2-chlorphenyl) -1, 4-benzodiazepine-4-oxide is obtained through post treatment. The preparation method does not need to use expensive raw materials for catalysis in the reaction process, does not need operations such as reaction quenching, solvent extraction, concentration distillation and the like in the post-treatment process, reduces the operation steps, shortens the production period, reduces the production cost, and is suitable for industrial production. |
| priorityDate | 2020-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.