| abstract |
The invention relates to a sitagliptin phosphate tablet. The tablet or tablet core comprises an active component of sitagliptin phosphate, a filler, a disintegrating agent and a lubricant. In the preparation process, the active component, the filler and the The disintegrant and the disintegrant are mixed uniformly, and then mixed with the lubricant for tableting. The invention uses microcrystalline cellulose and calcium sulfate as fillers, which can improve the shortcomings of poor fluidity and easy sticking of the active components, and the active components and auxiliary materials do not need to be pretreated during the preparation process, and the particle size of the materials is low. , the active components are not easy to adsorb containers and utensils, and the material utilization rate is high; when the batch is enlarged to 500,000 pieces/batch, no sticking phenomenon has been found, the preparation process is simple, the dissolution rate is fast, the product quality is excellent, and the stability is good. All indicators reached the ideal level of pharmacy. Suitable for large-scale commercial production. |