http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112481313-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-22 |
| filingDate | 2020-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112481313-B |
| titleOfInvention | A kind of enzymatic synthesis method of bimeprost intermediate |
| abstract | The invention relates to an enzymatic synthesis method of a bimeprost intermediate, which comprises the following steps: (1) cooling a mixed solution of oxalyl chloride and dichloromethane to -75--65°C, adding dimethyl sulfoxide After reacting with compound V for 1.5～3h, then adding triethylamine and warming up to -55～-45°C to react to prepare compound IV; (2) (2-oxo-4-phenylbutyl) dimethyl phosphate , lithium chloride is dissolved in acetonitrile and cooled to -10 ~ 0 ℃, add N, N-diisopropylethylamine and compound IV to carry out chemical reaction, prepare compound III; (3) compound III and potassium carbonate are at 20 ~ 25 ℃ to carry out chemical reaction to prepare compound II; (4) using compound II as a substrate, in the presence of ketocarbonyl reductase acetone powder, through a biocatalytic reaction to generate compound I, the specific synthetic route is as follows. |
| priorityDate | 2020-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.