| abstract |
The invention discloses a preparation method of an ectoin-hyaluronic acid composite gel and an obtained product, wherein a cross-linking agent EBD is prepared by a step method; and then EBD and BDDE are used as mixed cross-linking agents to perform cross-linking reaction with hyaluronic acid or salt thereof to prepare cross-linked hyaluronic acid gel, and free ectoin is added into the cross-linked hyaluronic acid gel again to be mixed to obtain the ectoin-hyaluronic acid composite gel. The invention contains free and cross-linked ectoine in two forms, not only has filling effect, but also has the functions of anti-aging and skin repair and regeneration in the whole hyaluronic acid gel filling period through the matching of the free and cross-linked ectoine in two forms, and has more potential and effect as viscoelastics for adjuvant therapy in glaucoma operation, lacrimal passage obstruction operation, vitrectomy and other operations. |