http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112479982-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-94 |
| filingDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112479982-B |
| titleOfInvention | A kind of preparation method of chiral indole-2,3-eight-membered carbocyclic compound |
| abstract | The invention discloses a preparation method of a chiral indole-2,3-8-membered carbocyclic compound, in particular: using palladium as a catalyst, through the joint action of a ligand and a silver salt, in an organic solvent, at room temperature The corresponding chiral indole-2,3-8-membered carbocyclic compound is generated by the reaction at a temperature of -100℃. The present invention uses easily prepared 2-(2-iodoarylamino) cyclooct-1-ene-1-carboxylate derivatives as raw materials, constructs a ring and a chemical bond in one step, and establishes a C2 benzylic position of indole in one step. The chiral center realizes the rapid construction of chiral indole-2,3-8-membered carbocyclic compounds. The reaction conditions are mild, the operation is simple, and the reaction raw materials are readily available, the substrate is widely applicable, the yield and enantioselectivity are excellent, and the target product is easily separated. |
| priorityDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.