| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_826cc5a41e1f477054b3bd82ef3c5d64 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-602 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3608
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-225
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-227
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3687 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-20 |
| filingDate |
2020-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04f59e804304f76777d72586bbd814f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_380a45042cb4cb23811fde221fae149a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a55b195e94221866508c6c135a9dda2f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a204f4cbe79333b4e0ad9884ed03bbe6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bd9174ca16fcb5d70330cca399b2001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c1945fe0847045130a3da301f851fc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_134684b498dbb79c2b10d31678a6ba29 |
| publicationDate |
2021-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-112472869-A |
| titleOfInvention |
A tissue-engineered bone scaffold for treating infectious large-segment bone defect and its preparation method and application |
| abstract |
The present invention discloses and provides a tissue engineering bone scaffold for treating infectious large-segment bone defect and a preparation method and application thereof, wherein the preparation method comprises: 1) soaking the decalcified bone matrix scaffold in a calcium chloride solution; 2) Mixing the sodium alginate solution containing IFN-γ with an appropriate amount of vancomycin solution to obtain a viscous solution; 3) slowly dripping the viscous solution into the pores of the demineralized bone matrix described in step 1), let stand, forming a composite scaffold; 4) after washing the composite scaffold with deionized water, cryopreserving it at -70°C, and then lyophilizing it until the weight no longer changes; 5) immersing the material obtained in step 4) into fibrin-containing After being slowly stirred in the original KH 2 PO 4 solution, immersed in the thrombin solution and slowly stirred for a period of time, taken out and air-dried at room temperature to obtain a tissue engineering bone scaffold. The invention also discloses the prepared tissue engineering bone scaffold and its application. The tissue engineered bone scaffold provided by the present invention can sequentially release inflammatory factors, promote angiogenesis and prevent infection. |
| priorityDate |
2020-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |