http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112472815-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02 |
| filingDate | 2020-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112472815-B |
| titleOfInvention | A kind of selenopeptide and its preparation method and application |
| abstract | The present invention provides a selenopeptide, a preparation method and application thereof, wherein the selenopeptide comprises an oxidation response unit, an enzyme response fragmentation unit and a tumor targeting unit sequentially connected from the N-terminus to the C-terminus; wherein, the oxidation-responsive unit The unit includes an oxidation-responsive selenium amino acid, and the oxidation-responsive selenium amino acid is aliphatic chain-L-selenocysteine. The present invention also provides a self-assembled selenopeptide nanomedicine, and the self-assembled selenopeptide nanomedicine includes the selenopeptide and an antitumor drug. The oxidation-responsive selenoamino acid of the present invention has the ability to respond sensitively to the oxidative environment, the selenopeptide has the ability to target tumors, reduce particle size through enzymatic cleavage to increase permeability, and accelerate drug release in tumor cells, The self-assembled selenopeptide nanomedicine composed of antitumor drugs has excellent tumor treatment effect, low toxicity and side effects, and broad application prospects. |
| priorityDate | 2020-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.