http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112472795-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate | 2020-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112472795-B |
| titleOfInvention | Biologics for Inhibiting Cellular Response to Stimulation by Inflammatory Factors |
| abstract | The invention belongs to the technical field of biomedicine, and discloses a biological preparation for inhibiting the response of cells to inflammatory factor stimulation, the biological preparation comprises a PRD peptide segment and/or a TAD peptide segment, and the amino acid sequence of the PRD peptide segment is as shown in SEQ ID NO: 1, the amino acid sequence of the PRD peptide segment is shown in SEQ ID NO: 2. The present invention finds out that the PRD peptide segment is a positive regulatory region in the YAP1 protein that inhibits the inflammatory stimulus response, and the TAD peptide segment is a negative regulatory region in the YAP1 protein that inhibits the inflammatory stimulus response; both are The signaling pathway of TNF-α, IL-1β, and LPS can be inhibited, and this finding provides a new approach for immunotherapy because PRD peptides and/or TAD peptides can be used in diseases caused by excessive cytokine production. |
| priorityDate | 2020-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 358.